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. 1985 Dec;43(3 Pt 2):615-21.
doi: 10.1016/0092-8674(85)90233-8.

ras proteins can induce meiosis in Xenopus oocytes

C Birchmeier, D Broek, M Wigler

ras proteins can induce meiosis in Xenopus oocytes

C Birchmeier et al. Cell. 1985 Dec.

Abstract

Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.

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