doi: 10.1016/0092-8674(85)90233-8.
ras proteins can induce meiosis in Xenopus oocytes
- PMID: 2416466
- DOI: 10.1016/0092-8674(85)90233-8
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ras proteins can induce meiosis in Xenopus oocytes
Cell.
1985 Dec.
Abstract
Injection of human H-ras protein induces maturation of Xenopus oocytes; that is, progression from prophase to metaphase of meiosis. The oncogenic protein encoded by H-rasval12 is nearly a 100-fold more potent than the protein encoded by the wild-type gene. We do not observe any measurable increase or decrease in cyclic AMP concentration in injected oocytes, and the effects of H-ras protein are only partially blocked by cholera toxin. Our results suggest that not all, if any, of the effects of H-rasval12 protein in this system are mediated by adenylate cyclase.
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