Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Oct 25;18(11):13260-70.
doi: 10.3390/molecules181113260.

Isosakuranetin-5-O-rutinoside: a new flavanone with antidepressant activity isolated from Salvia elegans Vahl

Manáses González-Cortazar  1 , Ana María Maldonado-Abarca, Enrique Jiménez-Ferrer, Silvia Marquina, Elsa Ventura-Zapata, Alejandro Zamilpa, Jaime Tortoriello, Maribel Herrera-Ruiz
Affiliations

Isosakuranetin-5-O-rutinoside: a new flavanone with antidepressant activity isolated from Salvia elegans Vahl

Manáses González-Cortazar et al. Molecules. .

Abstract

Ursolic acid (1) and a new flavanone, 5-O-(6-rhamnosylglucoside)-7-hydroxy-4'-methoxyflavanone (2), were isolated from the leaves of Salvia elegans Vahl. These natural products displayed antidepressant activity in mice as determined by means of a forced swimming test (FST) evaluation. Structural elucidation was carried out by chemical derivatization (acetylation) and spectroscopic analyses, such as 1H- and 13C-NMR and two-dimensional (2-D) COSY, heteronuclear multiple quantum coherence (HMQC), and heteronuclear multiple-bond correlation (HMBC) spectroscopy experiments.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Effect produced by oral administration of the Salvia elegans hydroalcoholic extract (SeHA, 250 and 500 mg/kg) and comparison with the treatment with Imipramine (IMI, 15 mg/kg) and Vehicle (Veh, 1.0% Tween [TW] 20) on immobility time in FST. Statistical analysis was carried out with Analysis of variance (ANOVA) followed by the post hoc Dunnett test (n = 8: mean ± standard deviation [SD]) (* p < 0.05).
Figure 2
Figure 2
Effect produced by different sub-fractions, SeF1, SeF2, and SeF3 (orally, 250 mg/kg) obtained from Salvia elegans, as well as imipramine (IMI, 15 mg/kg, intraperitoneally [i.p.]) and the vehicle (Veh, 1.0% Tween [TW] 20) administered to mice in the FST. Statistical analysis was carried out with Analysis of variance (ANOVA) followed by the post hoc Dunnett test (n = 8; mean ± standard deviation [SD]) (* p < 0.05).
Figure 3
Figure 3
HMBC correlations for C-3, C-5, C-1', H-2, H-1″ and H-1‴.
Figure 4
Figure 4
Ursolic acid (1), isosakuranetin-5-O-rutinoside (2), and isosakuranetin-5O-rutinoside heptaacetate (2a).
See this image and copyright information in PMC

References

    1. Gaffrey MS., Luby JL., Barch DM. Towards the study of functional brain development in depression: an interactive specialization approach. Neurobiol. Disease. 2013;52:38–48. doi: 10.1016/j.nbd.2012.06.012. - DOI - PMC - PubMed
    1. World Health Organization (WHO) [(accessed 9, October, 2012)]. Available online: http://www.who.int/mediacentre/news/notes/2012/mental_health_day_2012100...
    1. Nash J., Nutt D. Antidepressants. Psychiatry. 2007;6:289–294. doi: 10.1016/j.mppsy.2007.04.005. - DOI
    1. Moussavi S., Chatterji S., Verdes E., Tandon A., Patel V., Ustun B. Depression, chronic diseases, and decrements in health: Results from the World Health Surveys. Lancet. 2007;370:851–858. doi: 10.1016/S0140-6736(07)61415-9. - DOI - PubMed
    1. Rosua J.L., Blanca G. Revisión del género Salvia L. (Lamiaceae) en el mediterráneo occidental: La sección de Salvia. Acta Bot. Malacit. 1986;11:227–272.

Publication types

LinkOut - more resources