Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Nov;16(11):1537-43.
doi: 10.1038/nn.3546. Epub 2013 Oct 28.

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli  1 , Lisa M Monteggia
Affiliations
Review

mTOR complexes in neurodevelopmental and neuropsychiatric disorders

Mauro Costa-Mattioli et al. Nat Neurosci. 2013 Nov.

Abstract

The mechanistic target of rapamycin (mTOR) acts as a highly conserved signaling "hub" that integrates neuronal activity and a variety of synaptic inputs. mTOR is found in two functionally distinct complexes, mTORC1 and mTORC2, that crucially control long-term synaptic efficacy and memory storage. Dysregulation of mTOR signaling is associated with neurodevelopmental and neuropsychiatric disorders. In this Review, we describe the most recent advances in studies of mTOR signaling in the brain and the possible mechanisms underlying the many different functions of the mTOR complexes in neurological diseases. In addition, we discuss the medical relevance of these findings.

PubMed Disclaimer

References

    1. Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4738-43 - PubMed
    1. Neuron. 2008 Dec 26;60(6):950-60 - PubMed
    1. Lancet. 2013 Jan 12;381(9861):125-32 - PubMed
    1. Nat Rev Neurosci. 2008 May;9(5):344-56 - PubMed
    1. Nature. 2013 Jan 17;493(7432):371-7 - PubMed

Publication types

MeSH terms

Substances