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Comment
. 2013 Nov;45(11):1268-9.
doi: 10.1038/ng.2805.

Linking the SWI/SNF complex to prostate cancer

Ryan S Lee  1 , Charles W M Roberts
Affiliations
Comment

Linking the SWI/SNF complex to prostate cancer

Ryan S Lee et al. Nat Genet. 2013 Nov.

Abstract

Genes encoding subunits of the SWI/SNF chromatin-remodeling complex constitute, collectively, one of the most frequently mutated targets in cancer. Although mutations in SWI/SNF genes are uncommon in prostate cancer, a new study shows that SChLAP1, a long noncoding RNA frequently expressed in aggressive prostate tumors, drives cancer by directly disrupting SNF5, a core subunit of the SWI/SNF complex.

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Comment on

  • The long noncoding RNA SChLAP1 promotes aggressive prostate cancer and antagonizes the SWI/SNF complex.
    Prensner JR, Iyer MK, Sahu A, Asangani IA, Cao Q, Patel L, Vergara IA, Davicioni E, Erho N, Ghadessi M, Jenkins RB, Triche TJ, Malik R, Bedenis R, McGregor N, Ma T, Chen W, Han S, Jing X, Cao X, Wang X, Chandler B, Yan W, Siddiqui J, Kunju LP, Dhanasekaran SM, Pienta KJ, Feng FY, Chinnaiyan AM. Prensner JR, et al. Nat Genet. 2013 Nov;45(11):1392-8. doi: 10.1038/ng.2771. Epub 2013 Sep 29. Nat Genet. 2013. PMID: 24076601 Free PMC article.

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