Review
doi: 10.1055/s-0033-1358602.
Epub 2013 Oct 28.
Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children
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- PMID: 24166146
- DOI: 10.1055/s-0033-1358602
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Review
Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children
Neuropediatrics.
2013 Dec.
Abstract
The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell-dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.
Georg Thieme Verlag KG Stuttgart · New York.
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