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Review
. 2013 Dec;44(6):297-301.
doi: 10.1055/s-0033-1358602. Epub 2013 Oct 28.

Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children

Kevin Rostasy  1 , Markus Reindl
Affiliations
Review

Role of autoantibodies in acquired inflammatory demyelinating diseases of the central nervous system in children

Kevin Rostasy et al. Neuropediatrics. 2013 Dec.

Abstract

The recent detection of aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG) autoantibodies in acquired inflammatory demyelinating diseases, such as neuromyelitis optica, or acute disseminated encephalomyelitis, and multiple sclerosis, in children strongly indicates that B-cell-dependent mechanisms contribute to the pathogenesis. This review aims to give an overview of the role of autoantibodies in inflammatory demyelinating pediatric diseases, with a focus on antibodies to AQP4 and MOG.

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