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Meta-Analysis
. 2013 Oct 29:3:3075.
doi: 10.1038/srep03075.

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

Patrick Sleiman  1 , Dai Wang, Joseph Glessner, Dexter Hadley, Raquel E Gur, Nadine Cohen, Qingqin Li, Hakon Hakonarson; Janssen-CHOP Neuropsychiatric Genomics Working Group
Collaborators, Affiliations
Meta-Analysis

GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus

Patrick Sleiman et al. Sci Rep. .

Abstract

We carried out a GWAS meta-analysis of combined mixed-ancestry schizophrenia, schizoaffective, and bipolar cohorts that resulted in the identification of six genome-wide significant loci, including one novel locus at chr8q24.3, encompassing TSNARE1 (P = 1.28 × 10(-9)). The analysis included a total of 13,394 cases and 34,676 controls. While the function of TSNARE1 remains unknown, bioinformatic predictions based on phylogenetic ancestry indicate it may have a vertebrate-specific function in intracellular protein transport and synaptic vesicle exocytosis.

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Conflict of interest statement

Dr. Cohen is a former employee of Janssen Research & Development. Drs. Wang and Li are current employees of Janssen Research & Development.

Figures

Figure 1
Figure 1. Manhattan plot of the SCZ-BP meta-analysis.
The red dotted line indicates genome wide significance threshold of 5 × 10−8. Loci highlighted in red surpassed the genome-wide significance threshold in this study.
Figure 2
Figure 2. TSNARE1 regional association plot.
See this image and copyright information in PMC

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