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Meta-Analysis
. 2013 Oct 29;2013(10):CD003195.
doi: 10.1002/14651858.CD003195.pub3.

Urodynamic studies for management of urinary incontinence in children and adults

Affiliations
Meta-Analysis

Urodynamic studies for management of urinary incontinence in children and adults

Keiran David Clement et al. Cochrane Database Syst Rev. .

Abstract

Background: Urodynamic tests are used to investigate people who have urinary incontinence or other urinary symptoms in order to make a definitive, objective diagnosis. The aim is to help select the treatment most likely to be successful. The investigations are invasive and time consuming.

Objectives: The objective of this review was to determine if treatment according to a urodynamic-based diagnosis, compared to treatment based on history and examination, led to more effective clinical care of people with urinary incontinence and better clinical outcomes.The intention was to test the following hypotheses in predefined subgroups of people with incontinence:(i) urodynamic investigations improve the clinical outcomes;(ii) urodynamic investigations alter clinical decision making;(iii) one type of urodynamic test is better than another in improving the outcomes of management of incontinence or influencing clinical decisions, or both.

Search methods: We searched the Cochrane Incontinence Group Specialised Register, which contains trials identified from the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE and MEDLINE In-Process, handsearching of journals and conference proceedings (searched 19 February 2013), and the reference lists of relevant articles.

Selection criteria: Randomised and quasi-randomised trials comparing clinical outcomes in groups of people who were and were not investigated using urodynamics, or comparing one type of urodynamic test against another were included. Trials were excluded if they did not report clinical outcomes.

Data collection and analysis: Two review authors independently assessed trial quality and extracted data.

Main results: Eight trials involving around 1100 people were included but data were only available for 1036 women in seven trials, of whom 526 received urodynamics. There was some evidence of risk of bias. The four deaths and 12 dropouts in the control arm of one trial were unexplained.There was significant evidence that the tests did change clinical decision making. Women in the urodynamic arms of three trials were more likely to have their management changed (proportion with change in management compared with the control arm 17% versus 3%, risk ratio (RR) 5.07, 95% CI 1.87 to 13.74), although there was statistical heterogeneity. There was evidence from two trials that women treated after urodynamic investigations were more likely to receive drugs (RR 2.09, 95% CI 1.32 to 3.31). On the other hand, in five trials women undergoing treatment following urodynamic investigation were not more likely to undergo surgery (RR 0.99, 95% CI 0.88 to 1.12).There was no statistically significant difference however in the number of women with urinary incontinence if they received treatment guided by urodynamics (37%) compared with those whose treatment was based on history and clinical findings alone (36%) (for example, RR for the number with incontinence after the first year 1.02, 95% CI 0.86 to 1.21). It was calculated that the number of women needed to treat was 100 women (95% CI 86 to 114 women) undergoing urodynamics to prevent one extra individual being incontinent at one year.One trial reported adverse effects and no significant difference was found (RR 1.10, 95% CI 0.81 to 1.50).

Authors' conclusions: While urodynamic tests did change clinical decision making, there was some evidence that this did not result in better outcomes in terms of a difference in urinary incontinence rates after treatment. There was no evidence about their use in men, children, or people with neurological diseases. Larger definitive trials are needed in which people are randomly allocated to management according to urodynamic findings or to management based on history and clinical examination to determine if performance of urodynamics results in higher continence rates after treatment.

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Conflict of interest statement

None

Figures

1
1
PRISMA study flow diagram.
2
2
Risk of bias graph: review authors' judgements about each risk of bias item presented as percentages across all included studies.
3
3
Risk of bias summary: review authors' judgements about each risk of bias item for each included study.
1.1
1.1. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 1 Number with incontinence within first year (subjective).
1.2
1.2. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 2 Number with incontinence after first year (subjective).
1.3
1.3. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 3 Number with incontinence or not improved within first year (subjective).
1.4
1.4. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 4 Number with incontinence or not improved after first year (subjective).
1.5
1.5. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 5 Number treated conservatively.
1.6
1.6. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 6 Number treated with drugs.
1.7
1.7. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 7 Number treated with surgery.
1.8
1.8. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 8 Number whose treatment was changed after urodynamics.
1.9
1.9. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 9 Number not returning for further treatment.
1.10
1.10. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 10 Number not satisfied with treatment.
1.11
1.11. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 11 Number with urgency symptoms or urgency incontinence after treatment.
1.12
1.12. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 12 Volume/weight of urine lost on pad test.
1.13
1.13. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 13 Number of incontinence episodes in 24 hours.
1.14
1.14. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 14 Number with incontinence within first year (objective).
1.15
1.15. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 15 Number with incontinence after first year (objective).
1.16
1.16. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 16 Number with adverse events / complications.
1.17
1.17. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 17 Number with voiding dysfunction after treatment.
1.18
1.18. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 18 Deaths.
1.19
1.19. Analysis
Comparison 1 Urodynamics versus clinical management, Outcome 19 Health status measures.

Update of

Comment in

References

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Philip 2007 {published data only}
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Radley 2001 {published data only}
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Rehme 2009 {published data only}
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Robinson 2002 {published data only}
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Rovner 2005 {published data only}
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Sand 1985 {published data only}
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Scaldazza 2005 {published data only}
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Schmidt 2001 {published data only}
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Shukla 2006 {published data only}
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Sirls 2013 {published data only}
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Slack 2004 {published data only}
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Sullivan 1999 {published data only}
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Sullivan 2001 {published data only}
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Truzzi 1999 {published data only}
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Wadie 2009 {published data only}
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References to studies awaiting assessment

Romero Maroto 2010 {published data only}
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References to ongoing studies

Hilton 2011 {published data only}
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