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Comment
. 2013 Nov 15;19(22):6329-30.
doi: 10.1158/1078-0432.CCR-13-2007. Epub 2013 Oct 28.

Conjunctival melanomas harbor BRAF and NRAS mutations--Letter

Jaimie L Weber  1 , Keiran S M Smalley, Vernon K Sondak, Geoffrey T Gibney
Affiliations
Comment

Conjunctival melanomas harbor BRAF and NRAS mutations--Letter

Jaimie L Weber et al. Clin Cancer Res. .
No abstract available

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Figures

Figure 1
Figure 1
Staging scans at baseline and after 2 months of vemurafenib therapy in a patient with metastatic BRAF V600E–mutant conjunctival melanoma. A and B, marked growth in a left axillary lymph node mass. C and D, progression of a peripancreatic lymph node mass. E and F, modest regression in a mesenteric mass along with significant growth in a right paraspinal mass.
See this image and copyright information in PMC

Comment in

  • Conjunctival melanomas harbor BRAF and NRAS mutations--response.
    Griewank KG, Westekemper H, Schilling B, Livingstone E, Schimming T, Sucker A, Hillen U, Steuhl KP, Zimmer L, Schadendorf D. Griewank KG, et al. Clin Cancer Res. 2013 Nov 15;19(22):6331-2. doi: 10.1158/1078-0432.CCR-13-2368. Epub 2013 Oct 29. Clin Cancer Res. 2013. PMID: 24170549 No abstract available.

Comment on

References

    1. Griewank KG, Westekemper H, Murali R, Mach M, Schilling B, Wiesner T, et al. Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin Cancer Res. 2013;19:3143–52. - PubMed
    1. Lake SL, Jmor F, Dopierala J, Taktak AF, Coupland SE, Damato BE. Multiplex ligation-dependent probe amplification of conjunctival melanoma reveals common BRAF V600E gene mutation and gene copy number changes. Invest Ophthalmol Vis Sci. 2011;52:5598–604. - PubMed
    1. Jang S, Atkins MB. Which drug, and when, for patients with BRAF-mutant melanoma? Lancet Oncol. 2013;14:e60–9. - PubMed
    1. Westekemper H, Karimi S, Susskind D, Anastassiou G, Freistuhler M, Steuhl KP, et al. Expression of HSP 90, PTEN and Bcl-2 in conjunctival melanoma. Br J Ophthalmol. 2011;95:853–8. - PubMed
    1. Nathanson KL, Martin AM, Wubbenhorst B, Greshock J, Letrero R, D'Andrea K, et al. Tumor genetic analyses of patients with metastatic melanoma treated with the BRAF inhibitor dabrafenib (GSK2118436) Clin Cancer Res. 2013;19:4868–78. - PMC - PubMed