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. 2014 Jan;49(1):1-7.
doi: 10.1002/ppul.22933. Epub 2013 Oct 25.

Uncertain diagnosis after newborn screening for cystic fibrosis: An ethics-based approach to a clinical dilemma

John Massie  1 , Lynn Gillam
Affiliations

Uncertain diagnosis after newborn screening for cystic fibrosis: An ethics-based approach to a clinical dilemma

John Massie et al. Pediatr Pulmonol. 2014 Jan.

Abstract

There is uncertainty about the diagnosis of cystic fibrosis after newborn screening (NBS) for some babies, either because of an intermediate sweat chloride test or inconclusive gene mutation analysis. There is considerable difficulty knowing how best to manage these babies, some of whom will develop cystic fibrosis, but many not. This article offers an ethics-based approach to this clinical dilemma that should be helpful to clinicians managing the baby with an uncertain diagnosis of cystic fibrosis after NBS.

Keywords: cystic fibrosis; ethics; newborn screening.

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Comment in

  • Indeterminate cystic fibrosis newborn screening results.
    Ren CL, Parad R, Borowitz D. Ren CL, et al. Pediatr Pulmonol. 2015 Feb;50(2):209-10. doi: 10.1002/ppul.23055. Epub 2014 Apr 24. Pediatr Pulmonol. 2015. PMID: 24760681 No abstract available.
  • The authors reply.
    Massie J, Gillam L. Massie J, et al. Pediatr Pulmonol. 2015 Feb;50(2):211. doi: 10.1002/ppul.23072. Epub 2014 Jun 25. Pediatr Pulmonol. 2015. PMID: 24965175 No abstract available.