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Review
. 2014 May;49(5):503-7.
doi: 10.1002/ppul.22937. Epub 2013 Oct 25.

Omalizumab therapy for allergic bronchopulmonary aspergillosis in children with cystic fibrosis: a synthesis of published evidence

Kalliopi Tanou  1 , Elias Zintzaras, Athanasios G Kaditis
Affiliations
Review

Omalizumab therapy for allergic bronchopulmonary aspergillosis in children with cystic fibrosis: a synthesis of published evidence

Kalliopi Tanou et al. Pediatr Pulmonol. 2014 May.

Abstract

Allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis (CF) is treated with corticosteroids. Since elevated IgE is a cardinal abnormality, anti-IgE has been used sporadically as adjuvant treatment. In eight case reports, 13 children with CF and ABPA received anti-IgE resulting in improved FEV1 , fewer respiratory symptoms and decreased corticosteroid use.

Keywords: A. fumigatus; ABPA; anti-IgE.

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