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Comment
. 2013 Oct;10(10):e1001537.
doi: 10.1371/journal.pmed.1001537. Epub 2013 Oct 22.

Utility of the Xpert MTB/RIF assay for diagnosis of tuberculous meningitis

David R Boulware  1
Affiliations
Comment

Utility of the Xpert MTB/RIF assay for diagnosis of tuberculous meningitis

David R Boulware. PLoS Med. 2013 Oct.

Abstract

David Boulware discusses the challenges of diagnosing tuberculous meningitis and the implications of the study by Patel and colleagues using the Xpert MTB/RIF assay for diagnosis. Please see later in the article for the Editors' Summary.

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Conflict of interest statement

DRB receives support from the U.S. National Institutes of Health for research projects on the diagnosis and management of meningitis in resource-limited settings (R01NS086312-01).

Comment on

References

    1. Patel VB, Theron G, Lenders L, Matinyenya B, Connolly C, et al. (2013) Quantitative PCR (GeneXpert MTB/RIF) for the diagnosis of tuberculous meningitis in HIV-infected patients from a high burden setting: a prospective study. PLoS Med 10 ((10)) e1001536 doi:10.1371/journal.pmed.1001536 - DOI - PMC - PubMed
    1. Blakemore R, Story E, Helb D, Kop J, Banada P, et al. (2010) Evaluation of the analytical performance of the Xpert MTB/RIF assay. J Clin Microbiol 48: 2495–2501. - PMC - PubMed
    1. Helb D, Jones M, Story E, Boehme C, Wallace E, et al. (2010) Rapid detection of Mycobacterium tuberculosis and rifampin resistance by use of on-demand, near-patient technology. J Clin Microbiol 48: 229–237. - PMC - PubMed
    1. Raja S, Ching J, Xi L, Hughes SJ, Chang R, et al. (2005) Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing. Clin Chem 51: 882–890. - PubMed
    1. World Health Organization (2013) WHO monitoring of Xpert MTB/RIF roll-out. Available: http://www.who.int/tb/laboratory/mtbrifrollout/en/index.html. Accessed 1 September 2013.

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