Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2013 Oct;10(10):e1001539.
doi: 10.1371/journal.pmed.1001539. Epub 2013 Oct 22.

A transcriptional signature for active TB: have we found the needle in the haystack?

Adithya Cattamanchi  1 , Nicholas D Walter, John Z Metcalfe, J Lucian Davis
Affiliations
Comment

A transcriptional signature for active TB: have we found the needle in the haystack?

Adithya Cattamanchi et al. PLoS Med. 2013 Oct.

Abstract

Adithya Cattamanchi and colleagues reflect on recent research by Michael Levin and coworkers into the use of whole blood mRNA expression signatures to detect tuberculosis. The authors highlight challenges faced in getting this promising technology into clinics in low-resource settings. Please see later in the article for the Editors' Summary.

PubMed Disclaimer

Conflict of interest statement

J. Lucian Davis is involved in additional research concerning blood gene expression profiling and tuberculosis. The other authors have declared that no competing interests exist.

Comment on

References

    1. Berry MP, Graham CM, McNab FW, Xu Z, Bloch SA, et al. (2010) An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis. Nature 466: 973–977. - PMC - PubMed
    1. Jacobsen M, Repsilber D, Gutschmidt A, Neher A, Feldmann K, et al. (2007) Candidate biomarkers for discrimination between infection and disease caused by Mycobacterium tuberculosis. J Mol Med (Berl) 85: 613–621. - PubMed
    1. Koth LL, Solberg OD, Peng JC, Bhakta NR, Nguyen CP, et al. (2011) Sarcoidosis blood transcriptome reflects lung inflammation and overlaps with tuberculosis. Am J Respir Crit Care Med 184: 1153–1163. - PMC - PubMed
    1. Maertzdorf J, Weiner J 3rd, Mollenkopf HJ, Bauer T, Prasse A, et al. (2012) Common patterns and disease-related signatures in tuberculosis and sarcoidosis. Proc Natl Acad Sci U S A 109: 7853–7858. - PMC - PubMed
    1. Whiting P, Rutjes AW, Reitsma JB, Glas AS, Bossuyt PM, et al. (2004) Sources of variation and bias in studies of diagnostic accuracy: a systematic review. Ann Intern Med 140: 189–202. - PubMed

Publication types