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. 2013;76(17):1003-6.
doi: 10.1080/15287394.2013.830585.

Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice

Aline Lima de Barros  1 , Vanessa Vilamaior de Souza, Stephanie Dynczuki Navarro, Silvia Aparecida Oesterreich, Rodrigo Juliano Oliveira, Cândida Aparecida Leite Kassuya, Arielle Cristina Arena
Affiliations

Genotoxic and mutagenic effects of diflubenzuron, an insect growth regulator, on mice

Aline Lima de Barros et al. J Toxicol Environ Health A. 2013.

Abstract

This study assessed the genotoxic and mutagenic potential of diflubenzuron (DFB) insecticide in mice. Mice were divided into five groups: group I: negative control; group II: positive control; group III: 0.3 mg/kg of DFB; group IV: 1 mg/kg of DFB; group V: 3 mg/kg DFB. Peripheral blood was collected for the comet assay and the micronucleus (MN) test. DFB increased incidence of comet formation at all doses tested. A rise in the frequency of MN in mouse peripheral blood was observed 24, 48, and 72 h postexposure at all doses tested. Data demonstrate that DFB exerts genotoxic and mutagenic effects in a dose-dependent manner.

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