Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Dec;15(12):899-904.
doi: 10.1111/jch.12205. Epub 2013 Oct 30.

Relationship between left ventricular geometry and soluble ST2 in a cohort of hypertensive patients

Dike B Ojji  1 , Lionel H Opie, Sandrine Lecour, Lydia Lacerda, Olusoji Adeyemi, Karen Sliwa
Affiliations

Relationship between left ventricular geometry and soluble ST2 in a cohort of hypertensive patients

Dike B Ojji et al. J Clin Hypertens (Greenwich). 2013 Dec.

Abstract

Left ventricular (LV) hypertrophy (LVH) is classified according to geometric pattern into 4 types: concentric hypertrophy, eccentric hypertrophy, concentric remodeling, and normal geometry. Prevalence of death and cardiovascular complications associated with hypertension depend on the geometric pattern. Although soluble ST2 levels, a novel cardiac biomarker of mechanical strain is increased in hypertension, the relationship with hypertensive LV geometric patterns has not been studied. The authors investigated the relationship between soluble ST2 levels and LV geometric patterns in a cohort of hypertensive patients. LVH was considered present when echocardiographic LV mass index exceeded 49.2 g/m(2.7) in men and 46.2 g/m(2.7) in women. Patients with concentric hypertrophy had higher soluble ST2 levels compared with patients with normal geometry (20.4±8.4 ng/mL vs 14.3±5.4 ng/mL, P<.002). Therefore, soluble ST2 level is not only affected by hypertensive LV, but may be a future biomarker in differentiating concentric hypertrophy from normal geometry in hypertension.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Receiver operator curve showing the sensitivity and specificity of soluble ST2 in differentiating concentric hypertrophy from normal geometry.
Figure 2
Figure 2
Receiver operator curve showing the sensitivity and specificity of soluble ST2 in differentiating hypertension without left ventricular hypertrophy (LVH) from hypertension with LVH.
See this image and copyright information in PMC

Comment in

References

    1. Levy D, Garrison RJ, Savage DD, et al. Prognostic implications of echocardiographically determined left ventricular mass in the Framingham heart study. N Engl J Med. 1990;322:1561–1566. - PubMed
    1. Shigemitsu Y, Hamada M, Mukai M, et al. Clinical evidence for an association between left ventricular geometric adaptation and extracardiac target organ damage in essential hypertension. J Hypertens. 1995;13:155–160. - PubMed
    1. Shigematsu Y, Hamada M, Ohtsuka T, et al. Left ventricular geometry as an independent predictor for extracardiac target organ damage in essential hypertension. Am J Hypertens. 1998;11:1171–1177. - PubMed
    1. Cuspidi C, Macca G, Michev I, et al. Left ventricular concentric remodeling and extracardiac target organ damage in essential hypertension. J Hum Hypertens. 2002;16:385–390. - PubMed
    1. Esquitin R, Razzouk L, Peterson GE, et al. Left ventricular hypertrophy by electrocardiography and echocardiography in the African American Study of Kidney Disease Cohort Study. J Am Soc Hypertens. 2012;6:193–200. - PubMed

Publication types

MeSH terms