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Comment
. 2013 Sep 17;110(38):E3547.
doi: 10.1073/pnas.1311721110.

Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc

Comment

Reply to Crispin et al.: Molecular model that accounts for the biological and physical properties of sialylated Fc

Peter Sondermann et al. Proc Natl Acad Sci U S A. .
No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Comment on

References

    1. Sondermann P, Pincetic A, Maamary J, Lammens K, Ravetch JV. General mechanism for modulating immunoglobulin effector function. Proc Natl Acad Sci USA. 2013;110(24):9868–9872. - PMC - PubMed
    1. Crispin M, Yu X, Bowden TA. Crystal structure of sialylated IgG Fc: Implications for the mechanism of intravenous immunoglobulin therapy. Proc Natl Acad Sci USA. 2013;110:E3544–E3546. - PMC - PubMed
    1. Krapp S, Mimura Y, Jefferis R, Huber R, Sondermann P. Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity. J Mol Biol. 2003;325(5):979–989. - PubMed
    1. Borrok MJ, Jung ST, Kang TH, Monzingo AF, Georgiou G. Revisiting the role of glycosylation in the structure of human IgG Fc. ACS Chem Biol. 2012;7(9):1596–1602. - PMC - PubMed
    1. Barb AW, et al. NMR characterization of immunoglobulin G Fc glycan motion on enzymatic sialylation. Biochemistry. 2012;51(22):4618–4626. - PMC - PubMed

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