Anticancer drugs: IDH2 drives cancer in vivo

Affiliations

Comment

Isabel Lokody. Nat Rev Drug Discov. 2013 Nov.

. 2013 Nov;12(11):826-7.

doi: 10.1038/nrd4160.

No abstract available

Comment on

Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition.
Chen C, Liu Y, Lu C, Cross JR, Morris JP 4th, Shroff AS, Ward PS, Bradner JE, Thompson C, Lowe SW. Chen C, et al. Genes Dev. 2013 Sep 15;27(18):1974-85. doi: 10.1101/gad.226613.113. Genes Dev. 2013. PMID: 24065765 Free PMC article.
Induction of sarcomas by mutant IDH2.
Lu C, Venneti S, Akalin A, Fang F, Ward PS, Dematteo RG, Intlekofer AM, Chen C, Ye J, Hameed M, Nafa K, Agaram NP, Cross JR, Khanin R, Mason CE, Healey JH, Lowe SW, Schwartz GK, Melnick A, Thompson CB. Lu C, et al. Genes Dev. 2013 Sep 15;27(18):1986-98. doi: 10.1101/gad.226753.113. Genes Dev. 2013. PMID: 24065766 Free PMC article.