Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain
- PMID: 24173880
- DOI: 10.1002/anie.201306295
Development of an activity-based probe and in silico design reveal highly selective inhibitors for diacylglycerol lipase-α in brain
Keywords: activity-based probe; drug discovery; endocannabinoid; hydrolases; proteomics.
Similar articles
-
Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33. doi: 10.1073/pnas.1522364112. Epub 2015 Dec 14. Proc Natl Acad Sci U S A. 2016. PMID: 26668358 Free PMC article.
-
Inhibitors of diacylglycerol lipases in neurodegenerative and metabolic disorders.Bioorg Med Chem Lett. 2016 Aug 15;26(16):3831-7. doi: 10.1016/j.bmcl.2016.06.076. Epub 2016 Jun 27. Bioorg Med Chem Lett. 2016. PMID: 27394666 Review.
-
Chemical tools to modulate 2-arachidonoylglycerol biosynthesis.Biotechnol Appl Biochem. 2018 Jan;65(1):9-15. doi: 10.1002/bab.1568. Epub 2017 Aug 2. Biotechnol Appl Biochem. 2018. PMID: 28589628 Review.
-
Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase.J Biochem. 2016 Nov;160(5):269-279. doi: 10.1093/jb/mvw034. Epub 2016 May 19. J Biochem. 2016. PMID: 27198176
-
CaMKII regulates diacylglycerol lipase-α and striatal endocannabinoid signaling.Nat Neurosci. 2013 Apr;16(4):456-63. doi: 10.1038/nn.3353. Epub 2013 Mar 17. Nat Neurosci. 2013. PMID: 23502535 Free PMC article.
Cited by
-
Structure-Activity Relationship Studies of α-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family.J Med Chem. 2020 Sep 10;63(17):9340-9359. doi: 10.1021/acs.jmedchem.0c00522. Epub 2020 Aug 13. J Med Chem. 2020. PMID: 32787138 Free PMC article.
-
Combining cross-metathesis and activity-based protein profiling: new β-lactone motifs for targeting serine hydrolases.Bioorg Med Chem Lett. 2015 Jan 15;25(2):317-21. doi: 10.1016/j.bmcl.2014.11.038. Bioorg Med Chem Lett. 2015. PMID: 25541002 Free PMC article.
-
Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Nat Chem Biol. 2015 Feb;11(2):164-71. doi: 10.1038/nchembio.1721. Epub 2015 Jan 12. Nat Chem Biol. 2015. PMID: 25580854 Free PMC article.
-
Activity-Based Protein Profiling Identifies α-Ketoamides as Inhibitors for Phospholipase A2 Group XVI.ACS Chem Biol. 2019 Feb 15;14(2):164-169. doi: 10.1021/acschembio.8b00969. Epub 2019 Jan 18. ACS Chem Biol. 2019. PMID: 30620559 Free PMC article.
-
ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction.ACS Chem Biol. 2019 Oct 18;14(10):2295-2304. doi: 10.1021/acschembio.9b00640. Epub 2019 Oct 1. ACS Chem Biol. 2019. PMID: 31525885 Free PMC article.
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Other Literature Sources