Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013:2013:985636.
doi: 10.1155/2013/985636. Epub 2013 Sep 22.

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats

Wei Qi  1 , Yang Zhang, Ya-Bo Yan, Wei Lei, Zi-Xiang Wu, Ning Liu, Shuai Liu, Lei Shi, Yong Fan
Affiliations

The Protective Effect of Cordymin, a Peptide Purified from the Medicinal Mushroom Cordyceps sinensis, on Diabetic Osteopenia in Alloxan-Induced Diabetic Rats

Wei Qi et al. Evid Based Complement Alternat Med. 2013.

Abstract

The aim of this study was to investigate the protective effect of cordymin on diabetic osteopenia in alloxan-induced diabetic rats and the possible mechanisms involved. The diabetic rats received daily intraperitoneal injection with cordymin (20, 50, and 100 mg/kg/day) for 5 weeks. Cordymin could restore the circulating blood glucose, glycosylated hemoglobin (HbA1c), serum alkaline phosphatase (ALP), tartrate resistant acid phosphatase (TRAP), and insulin levels in a dose-dependent manner. Also, the treatment of diabetic rats with cordymin could partially reverse the β cells death and decrease the total antioxidant status (TAOS) in the diabetic rats. The results may directly and indirectly account for the possible mechanism of the beneficial effect of cordymin on diabetic osteopenia, which was confirmed with the increased bone mineral content (BMC) and bone mineral density (BMD) in diabetic rats (P < 0.05). All those findings indicate that cordymin may play a protective role in diabetic osteoporosis.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Possible mechanisms through which diabetic conditions increase the risk of osteoporotic fractures (AGEs: advanced glycation end products).
Figure 2
Figure 2
Effects of cordymin on the weekly average body weights. Values are means ± SEM, n = 10. *Different from alloxan group P < 0.05; **different from alloxan group, P < 0.01.
Figure 3
Figure 3
Islet cell death and replication represented by hematoxylin-eosin. The islet cells of diabetic rats of alloxan treatment (a) showed extensive cell lysis, representing loss of plasma membrane with condensed nuclei and dissolved cytoplasm in wide intercellular spaces. In contrast, the islet cell of cordymin100-fed rat (b) was partly recovered. The islet cell of control rat was (c).
Figure 4
Figure 4
Effect of cordymin on total antioxidant. Activity values are shown as means ± SEM. *P < 0.05 versus alloxan group; **P < 0.01 versus alloxan group.
Figure 5
Figure 5
Effect of cordymin on bone mineral density (BMD). Values are shown as means ± SEM. *P < 0.05 versus alloxan group.
See this image and copyright information in PMC

References

    1. Zhang X, Shi P, Cao S, Yu H, Azad J, Ling S. Expression changes of transforming growth factor-beta1 and thrombospondin-1 in cavernous tissues of diabetic rats. Urologia Internationalis. 2010;84(2):221–225. - PubMed
    1. Del Canizo Gomez FJ, Fernandez Perez C, Moreno Ruiz I, et al. Microvascular complications and risk factors in patients with type 2 diabetes. Endocrinología y Nutrición. 2011;58(4):163–168. - PubMed
    1. Lu B, Gong W, Yang Z, et al. An evaluation of the diabetic kidney disease definition in chinese patients diagnosed with type 2 diabetes mellitus. The Journal of International Medical Research. 2009;37(5):1493–1500. - PubMed
    1. Atsumi H, Kitada M, Kanasaki K, Koya D. Reversal of redox-dependent inhibition of diacylglycerol kinase by antioxidants in mesangial cells exposed to high glucose. Molecular Medicine Reports. 2011;4(5):923–927. - PubMed
    1. Yamamoto M, Yamaguchi T, Yamauchi M, Kaji H, Sugimoto T. Diabetic patients have an increased risk of vertebral fractures independent of BMD or diabetic complications. Journal of Bone and Mineral Research. 2009;24(4):702–709. - PubMed

LinkOut - more resources