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. 2013:2013:309493.
doi: 10.1155/2013/309493. Epub 2013 Sep 22.

Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model

Ken Yasukawa  1 , Yoshimasa Kasahara
Affiliations

Effects of Flavonoids from French Marigold (Florets of Tagetes patula L.) on Acute Inflammation Model

Ken Yasukawa et al. Int J Inflam. 2013.

Abstract

The major components patuletin and patulitrin were isolated from French marigold (florets of Tagetes patula). Patuletin and patulitrin were found to inhibit acute inflammation in mice. Oral administration of patuletin and patulitrin significantly suppressed hind-paw edema induced by carrageenin and histamine, while topical application of patuletin and patulitrin significantly inhibited ear edema induced by 12-O-tetradecanoylphorbol-13-acetate and arachidonic acid. Thus, oral and topical administration of patuletin and patulitrin inhibited acute inflammation in mice. These results suggest the anti-inflammatory efficacy of French marigold.

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Figures

Figure 1
Figure 1
The structures of flavonoids from Tagetes putula.
Figure 2
Figure 2
Inhibitory effect of patuletin on carrageenin-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before carrageenin (2%, 25 μL). ⚫: control; ■: patuletin 5 mg/kg; ▲: patuletin 15 mg/kg; ▼: patuletin 50 mg/kg; ♦: phenylbutazone 100 mg/kg. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
Figure 3
Figure 3
Inhibitory effect of patulitrin on carrageenin-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before carrageenin (2%, 25 μL). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: phenylbutazone 100 mg/kg. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
Figure 4
Figure 4
Inhibitory effect of patuletin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patuletin 5 mg/kg; ▲: patuletin 15 mg/kg; ▼: patuletin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
Figure 5
Figure 5
Inhibitory effect of patulitrin on histamine-induced hind-paw edema in mice. Drugs were administered p.o. 30 min before histamine (5 μg). ⚫: control; ■: patulitrin 5 mg/kg; ▲: patulitrin 15 mg/kg; ▼: patulitrin 50 mg/kg; ♦: cyproheptadine 10 mg/kg. Significantly different from the control, *P < 0.05 or **P < 0.01. Each value represents the mean ± SD of 5. Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 5 mice.
Figure 6
Figure 6
Inhibitory effect of patuletin and patulitrin on TPA-induced ear edema in mice. Drugs were administered topically 30 min before TPA (1 μg). Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 4 mice.
Figure 7
Figure 7
Inhibitory effect of patuletin and patulitrin on AA-induced ear edema in mice. Drugs were administered topically 30 min before AA (1 mg). Significantly different from the control, *P < 0.05, **P < 0.01, or ***P < 0.001. Each value represents the mean ± SD of 4 mice.
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