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. 2013 Nov 1:8:204.
doi: 10.1186/1749-8090-8-204.

Risk factors for early postoperative cognitive dysfunction after non-coronary bypass surgery in Chinese population

Tao Xu, Lulong Bo, Jiafeng Wang, Zhenzhen Zhao, Zhiyun Xu, Xiaoming Deng, Wenzhong Zhu  1
Affiliations

Risk factors for early postoperative cognitive dysfunction after non-coronary bypass surgery in Chinese population

Tao Xu et al. J Cardiothorac Surg. .

Abstract

Background: The present study was performed to investigate the incidence of early postoperative cognitive dysfunction (POCD) after non-coronary bypass surgery and the potential risk factors in Chinese population.

Methods: We performed a prospective study in a teaching tertiary hospital from May 2012 to August 2012. One hundred and seventy-six adult patients undergoing non-coronary bypass surgery were recruited. Mini-Mental State Examination (MMSE) score was evaluated before and 3 to 5 days after surgery. Patients with a MMSE score reduction of 2 was diagnosed with POCD.

Results: The general incidence of POCD was 33.0%, with no significant difference between the types of surgeries. In the univariate analysis, POCD associated factors included age, duration of surgery, anesthesia, cardiopulmonary bypass (CPB), cross-clamp and rewarming, and sevoflurane concentration. However, only age, cross-clamp duration and sevoflurane concentration were demonstrated to be independent risk factors for POCD.

Conclusion: Incidence of early POCD after non-coronary bypass surgery was relatively high in Chinese population. Advanced age, longer aortic cross-clamp duration and lower sevoflurane concentration was associated with a higher incidence of POCD.

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