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Review
. 2013 Dec;29(12):612-22.
doi: 10.1016/j.pt.2013.10.001. Epub 2013 Oct 29.

Escaping the immune system: How the malaria parasite makes vaccine development a challenge

Danielle I Stanisic  1 , Alyssa E Barry, Michael F Good
Affiliations
Review

Escaping the immune system: How the malaria parasite makes vaccine development a challenge

Danielle I Stanisic et al. Trends Parasitol. 2013 Dec.

Abstract

Malaria is a major cause of morbidity and mortality. Immunity is acquired but is suboptimal, being slow to develop and incomplete. An inadequate understanding of natural immunity, host-parasite interactions, and a lack of reliable immune correlates of protection that could predict vaccine efficacy in the field have hindered development of a vaccine. With data from Phase III trials indicating that the leading malaria vaccine candidate, RTS,S, has limited efficacy, it is necessary to reconsider approaches to the development of a vaccine capable of inducing long-lived protection.

Keywords: immune evasion; immunity; immunomodulation; malaria; vaccine.

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