Physical separation of "suppressor" from "helper" thymocytes
- PMID: 241768
Physical separation of "suppressor" from "helper" thymocytes
Abstract
Thymocytes from 1-month-old NZB/W mice were separated at unit gravity and then studied for helper or suppressor effects in a GVH assay. Thymocytes with a settling rate of 4 to 6 mm/hr suppressed but did not help. In contrast, help but no suppression characterized thymocytes settling at 6 to 10 mm/hr. Thus helper and suppressor thymocytes in this GVH assay were physically separated.
Similar articles
-
Loss with age in NZB-W mice of thymic suppressor cells in the graft-vs-host reaction.J Immunol. 1974 Nov;113(5):1618-25. J Immunol. 1974. PMID: 4153571 No abstract available.
-
Preparative nonlytic separation of Lyt2+ and Lyt2- T lymphocytes, functional analyses of the separated cells and demonstration of synergy in graft-vs.-host reaction of Lyt2+ and Lyt2- cells.Eur J Immunol. 1981 Mar;11(3):228-35. doi: 10.1002/eji.1830110312. Eur J Immunol. 1981. PMID: 6972307
-
Effect of physiological and pharmacologically induced thymus involution on the immunoreactivity in C57BL mice.Pol J Pharmacol. 2001 Jul-Aug;53(4):403-7. Pol J Pharmacol. 2001. PMID: 11990088
-
Supressor cells in the graft vs host reaction.J Immunol. 1973 Aug;111(2):650-1. J Immunol. 1973. PMID: 4146230 No abstract available.
-
Effect of graft-versus-host reaction on thymic function.Immunol Res. 1988;7(3):239-46. doi: 10.1007/BF02918139. Immunol Res. 1988. PMID: 3057090 Review. No abstract available.
Cited by
-
Heterogeneity of murine regulatory T cells. I. Subpopulations of amplifier and suppressor T cells.J Exp Med. 1976 Aug 1;144(2):398-413. doi: 10.1084/jem.144.2.398. J Exp Med. 1976. PMID: 1085327 Free PMC article.
-
Separation of helper and suppressor T lymphocytes on a ficoll velocity sedimentation gradient.J Exp Med. 1976 May 1;143(5):1199-210. doi: 10.1084/jem.143.5.1199. J Exp Med. 1976. PMID: 1083419 Free PMC article.
-
Studies on delayed hypersensitivity in mice. III. Evidence for suppressive regulatory T1-cell population in delayed hypersensitivity.J Exp Med. 1977 Feb 1;145(2):237-48. doi: 10.1084/jem.145.2.237. J Exp Med. 1977. PMID: 299878 Free PMC article.
-
Functional characterization of mouse lymphocyte subpopulations identified by their natural binding of bacteria. II. Identification of subpopulations of LY-1 + 2-3-, LY-1-2+3+ and LY-1+2+3+ cells and the localization of specific cytotoxic cells in a subset of LY-1-2+3+ cells.Immunology. 1981 Feb;42(2):285-95. Immunology. 1981. PMID: 6970178 Free PMC article.
-
Suppressor T cells prevent experimental autoimmune encephalomyelitis in mice.Clin Exp Immunol. 1977 Jul;29(1):100-9. Clin Exp Immunol. 1977. PMID: 302168 Free PMC article.