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. 2013 Oct 30;11(11):4294-317.
doi: 10.3390/md11114294.

Anxiolytic-like effect of a salmon phospholipopeptidic complex composed of polyunsaturated fatty acids and bioactive peptides

Nabila Belhaj  1 , Frédéric Desor, Céline Gleizes, Frédéric M Denis, Elmira Arab-Tehrany, Rachid Soulimani, Michel Linder
Affiliations

Anxiolytic-like effect of a salmon phospholipopeptidic complex composed of polyunsaturated fatty acids and bioactive peptides

Nabila Belhaj et al. Mar Drugs. .

Abstract

A phospholipopeptidic complex obtained by the enzymatic hydrolysis of salmon heads in green conditions; exert anxiolytic-like effects in a time and dose-dependent manner, with no affection of locomotor activity. This study focused on the physico-chemical properties of the lipidic and peptidic fractions from this natural product. The characterization of mineral composition, amino acid and fatty acids was carried out. Stability of nanoemulsions allowed us to realize a behavioral study conducted with four different tests on 80 mice. This work highlighted the dose dependent effects of the natural complex and its various fractions over a period of 14 days compared to a conventional anxiolytic. The intracellular redox status of neural cells was evaluated in order to determine the free radicals scavenging potential of these products in the central nervous system (CNS), after mice sacrifice. The complex peptidic fraction showed a strong scavenging property and similar results were found for the complex as well as its lipidic fraction. For the first time, the results of this study showed the anxiolytic-like and neuroprotective properties of a phospholipopeptidic complex extracted from salmon head. The applications on anxiety disorders might be relevant, depending on the doses, the fraction used and the chronicity of the supplementation.

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Figures

Figure 1
Figure 1
Transmission electron microscopy image of lipidic fraction mixed with distilled water.
Figure 2
Figure 2
Results of elevated plus maze (EPM) test (* p < 0.05, ** p < 0.01, *** p < 0.001).
Figure 3
Figure 3
Results of hole-board test (* p < 0.05, ** p < 0.01, *** p < 0.001).
Figure 4
Figure 4
Results of light-dark boxtest (* p < 0.05, ** p < 0.01, *** p < 0.001).
See this image and copyright information in PMC

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