Making sense of the antisense transcripts in C9FTD/ALS
- PMID: 24178412
- PMCID: PMC3916144
- DOI: 10.1007/s00401-013-1201-y
Making sense of the antisense transcripts in C9FTD/ALS
Comment on
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Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations.Acta Neuropathol. 2013 Dec;126(6):859-79. doi: 10.1007/s00401-013-1181-y. Epub 2013 Oct 6. Acta Neuropathol. 2013. PMID: 24096617
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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS.Acta Neuropathol. 2013 Dec;126(6):829-44. doi: 10.1007/s00401-013-1192-8. Epub 2013 Oct 16. Acta Neuropathol. 2013. PMID: 24129584 Free PMC article.
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Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins.Acta Neuropathol. 2013 Dec;126(6):881-93. doi: 10.1007/s00401-013-1189-3. Epub 2013 Oct 17. Acta Neuropathol. 2013. PMID: 24132570
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Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood.Acta Neuropathol. 2013 Dec;126(6):895-905. doi: 10.1007/s00401-013-1199-1. Epub 2013 Oct 29. Acta Neuropathol. 2013. PMID: 24166615 Free PMC article.
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C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci.Acta Neuropathol. 2013 Dec;126(6):845-57. doi: 10.1007/s00401-013-1200-z. Epub 2013 Oct 30. Acta Neuropathol. 2013. PMID: 24170096 Free PMC article.
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Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS.Acta Neuropathol. 2013 Dec;126(6):829-44. doi: 10.1007/s00401-013-1192-8. Epub 2013 Oct 16. Acta Neuropathol. 2013. PMID: 24129584 Free PMC article.
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Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood.Acta Neuropathol. 2013 Dec;126(6):895-905. doi: 10.1007/s00401-013-1199-1. Epub 2013 Oct 29. Acta Neuropathol. 2013. PMID: 24166615 Free PMC article.
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RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia.Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E4968-77. doi: 10.1073/pnas.1315438110. Epub 2013 Nov 18. Proc Natl Acad Sci U S A. 2013. PMID: 24248382 Free PMC article. Clinical Trial.
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Current insights into the C9orf72 repeat expansion diseases of the FTLD/ALS spectrum.Trends Neurosci. 2013 Aug;36(8):450-9. doi: 10.1016/j.tins.2013.04.010. Epub 2013 Jun 7. Trends Neurosci. 2013. PMID: 23746459 Review.
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