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. 1995 Dec;9(4):391-5.
doi: 10.1007/BF00807276.

Neuroexcitatory amino acids: 4-methylene glutamic acid derivatives : Short Communication

J M Receveur  1 , M L Roumestant, P Viallefont
Affiliations

Neuroexcitatory amino acids: 4-methylene glutamic acid derivatives : Short Communication

J M Receveur et al. Amino Acids. 1995 Dec.

Abstract

A short synthesis of 4-methylene glutamic acid was achieved. Under thermal conditions the corresponding anhydride reacted with 2,3 dimethylbutadiene to afford the corresponding DIELS-ALDER adduct in good yield. L-4-methylene glutamic acid essentially acts on glutamate metabotropic receptors and is as potent as L-Glu in producing IPs.

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