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Randomized Controlled Trial
. 2013 Dec;14(4):420-3.
doi: 10.1016/j.eatbeh.2013.07.007. Epub 2013 Jul 21.

Effect of nicotine patch on energy intake and weight gain in postmenopausal women during smoking cessation

Alicia M Allen  1 , Alison Kleppinger, Harry Lando, Cheryl Oncken
Affiliations
Randomized Controlled Trial

Effect of nicotine patch on energy intake and weight gain in postmenopausal women during smoking cessation

Alicia M Allen et al. Eat Behav. 2013 Dec.

Abstract

Introduction: Post-cessation weight gain is a commonly cited barrier to smoking cessation. Some evidence suggests that nicotine replacement therapy may limit post-cessation weight gain by reducing energy intake. This project aims to assess differential changes in energy intake and body weight during smoking cessation in a sample of postmenopausal women randomized to receive 21 mg nicotine or placebo patch for 12 weeks.

Methods: Postmenopausal women who smoked ≥10 cigarettes/day were enrolled in this double-blind randomized placebo-controlled study. Total energy intake (via four-day food diaries), body mass index (BMI; kg/m(2)), cigarettes/day and smoking status (self-report verified by exhaled carbon monoxide) were assessed at three time points: 2 weeks prior to quit date, 12 weeks after quit date, and 12 months after smoking cessation treatment.

Results: Participants (n = 119) were, on average, 55.8 ± 6.7 years old with a baseline BMI of 27.0 ± 5.2 and average cigarette/day was 21.1 ± 8.6. At Week 12, participants randomized to nicotine patch increased their mean caloric intake by 146.4 ± 547.7 kcal/day whereas those on placebo patch decreased their caloric intake by 175.3 ± 463.2 (f-value = 10.1, p-value = 0.002). Despite the differences in caloric intake, body weight remained similar between groups.

Conclusions: The results of this study indicate that nicotine patch may increase energy intake during treatment, and does not prevent post-cessation weight gain in postmenopausal smokers. Additional research is needed to replicate these findings and assess whether different forms of nicotine replacement therapy influence caloric intake and post-cessation weight gain in postmenopausal smokers.

Keywords: Energy intake; Nicotine patch; Postmenopausal; Smoking cessation; Weight gain.

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References

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