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. 2014 May 25;50(40):5336-8.
doi: 10.1039/c3cc47427e. Epub 2013 Nov 4.

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Duc Trung Bui  1 , Julien Nicolas, Andrei Maksimenko, Didier Desmaële, Patrick Couvreur
Affiliations

Multifunctional squalene-based prodrug nanoparticles for targeted cancer therapy

Duc Trung Bui et al. Chem Commun (Camb). .

Abstract

Fluorescent and biotinylated squalene-gemcitabine prodrug nanoparticles exhibiting high drug payloads have been prepared and successfully used to target different cancer cell lines, resulting in increased cell uptake and improved anticancer efficiency, which represents the first targeted system derived from the squalenoylation approach.

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