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Comment
. 2014 Jan;11(1):11-3.
doi: 10.1038/cmi.2013.49. Epub 2013 Nov 4.

The fate of regulatory T cells: survival or apoptosis

Chia-Rui Shen  1 , Wei-Cheng Yang  1 , Hsin-Wei Chen  2
Affiliations
Comment

The fate of regulatory T cells: survival or apoptosis

Chia-Rui Shen et al. Cell Mol Immunol. 2014 Jan.
No abstract available

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Figures

Figure 1
Figure 1
A proposed regulatory mechanism of Treg homeostasis and survival. In the steady state, the interactions between pro-apoptotic Bim, anti-apoptotic Mcl-1 and apoptotic regulators Bax and Bak actively maintain the homeostatic population of Tregs. When the homeostatic population of Tregs is disturbed, signals provided by IL-2 and costimulatory signals upregulate anti-apoptotic Mcl-1 expression, which in turn inhibits the Bak and Bax-mediated intrinsic apoptosis pathway and subsequently allows Tregs to proliferate during the niche-filling process. Treg, regulatory T cell.
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References

    1. Pierson W, Cauwe B, Policheni A, Schlenner SM, Franckaert D, Berges J, et al. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nat Immunol. 2013;14:959–965. - PMC - PubMed
    1. Fontenot JD, Gavin MA, Rudensky AY. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol. 2003;4:330–336. - PubMed
    1. Hori S, Nomura T, Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science. 2003;299:1057–1061. - PubMed
    1. Nishikawa H, Sakaguchi S. Regulatory T cells in tumor immunity. Int J Cancer. 2010;127:759–767. - PubMed
    1. Viglietta V, Baecher-Allan C, Weiner HL, Hafler DA. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med. 2004;199:971–979. - PMC - PubMed

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