Inhibition of the in vitro-reactivation of latent herpes simplex virus infection in spinal ganglia: comparison of various immune factors. Brief report

Abstract

In order to study whether the latency of herpes simplex virus (HSV) is immunologically controlled, the influence of different immune mechanisms on the in vitro-reactivation of the virus in latently infected lumbosacral ganglia of mice was investigated. Combined addition of macrophages and antibodies to cultures of ganglionic tissue proved most effective in delaying virus reactivation. This was achieved to a lesser degree when applying antibodies only, whereas macrophages alone were not effective, nor were immune lymphocytes, nor was interferon from L-cells or from the peritoneal cavity of mice.