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. 2014 Mar;54(3 Pt 2):942-55.
doi: 10.1111/trf.12468. Epub 2013 Nov 4.

The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): a research program striving to improve blood donor and transfusion recipient outcomes

Steven Kleinman  1 , Michael P Busch, Edward L Murphy, Hua Shan, Paul Ness, Simone A Glynn; National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III)
Collaborators, Affiliations

The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): a research program striving to improve blood donor and transfusion recipient outcomes

Steven Kleinman et al. Transfusion. 2014 Mar.

Abstract

Background: The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute.

Study design and methods: The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa, which involve US and in-country investigators.

Results: REDS-III is using two major methods to address key research priorities in blood banking and transfusion medicine. First, there will be numerous analyses of large "core" databases; the international programs have each constructed a donor and donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Second, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that either are in progress or are scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization, transfusion outcomes, noninfectious transfusion risks, human immunodeficiency virus-related safety issues (particularly in the international programs), emerging infectious agents, blood component quality, donor health and safety, and other donor issues.

Conclusions: It is intended that REDS-III serve as an impetus for more widespread recipient and linked donor-recipient research in the United States as well as to help assure a safe and available blood supply in the United States and in international locations.

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Conflict of interest statement

Conflict of Interest statement

Each of the authors declares that he/she has no conflicts of interest regarding any of the work presented in this publication

Figures

Figure 1
Figure 1. REDS-III Institutional Infrastructure
Coordination of institutions participating in REDS -III Abbreviations: ARC - American Red Cross; BCP – Blood Centers of the Pacific; BCW- BloodCenter of Wisconsin; BSRI - Blood Systems Research Institute; CL- Central Laboratory: DCC - Data Coordinating Center: IBT - Chinese Institute of Blood Transfusion; ITXM - The Institute For Transfusion Medicine; JHU -Johns Hopkins University; NHLBI – National Heart Lung and Blood Institute; RTI – RTI International; SANBS - South African National Blood Service; UCSF - University of California, San Francisco; Yale - Yale University School of Medicine
See this image and copyright information in PMC

References

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