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. 2014 Mar 28;344(2):204-11.
doi: 10.1016/j.canlet.2013.10.030. Epub 2013 Nov 1.

MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer

Qingyu Shen  1 , Hyun Jin Bae  1 , Jung Woo Eun  1 , Hyung Seok Kim  1 , Se Jin Park  1 , Woo Chan Shin  1 , Eun Kyung Lee  2 , Soha Park  3 , Won Sang Park  1 , Jung Young Lee  1 , Suk Woo Nam  4
Affiliations

MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer

Qingyu Shen et al. Cancer Lett. .

Abstract

Nemo-like kinase (NLK), an evolutionarily conserved MAP kinase-related kinase, has been reported to be involved in the development of hepatocellular carcinoma (HCC), but the underlying mechanisms leading to oncogenic NLK are poorly understood. A comprehensive microRNA (miRNA) profiling analysis on human HCC tissues identified four downregulated miRNAs that may target NLK. Ectopic expression of miRNA mimics suggested that miR-101 could suppress NLK in HCC cells. Notably, ectopic miR-101 expression repressed cancer cell growth and proliferation and imitated NLK knockdown effect on HCC cells. In conclusion, we suggest that miR-101 functions as a tumor suppressor by regulating abnormal NLK activity in liver.

Keywords: Liver cancer; MiR-101; NLK; Tumor suppressor.

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