Slipping past the spindle assembly checkpoint
- PMID: 24189515
- DOI: 10.1038/ncb2876
Slipping past the spindle assembly checkpoint
Abstract
Error-free genome segregation depends on the spindle assembly checkpoint (SAC), a signalling network that delays anaphase onset until chromosomes have established proper spindle attachments. Three reports now quantitatively examine the sensitivity and robustness of the SAC response.
Comment on
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The spindle assembly checkpoint works like a rheostat rather than a toggle switch.Nat Cell Biol. 2013 Nov;15(11):1378-85. doi: 10.1038/ncb2855. Epub 2013 Oct 6. Nat Cell Biol. 2013. PMID: 24096242 Free PMC article.
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Kinetic framework of spindle assembly checkpoint signalling.Nat Cell Biol. 2013 Nov;15(11):1370-7. doi: 10.1038/ncb2842. Epub 2013 Oct 6. Nat Cell Biol. 2013. PMID: 24096243 Free PMC article.
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Determinants of robustness in spindle assembly checkpoint signalling.Nat Cell Biol. 2013 Nov;15(11):1328-39. doi: 10.1038/ncb2864. Epub 2013 Oct 27. Nat Cell Biol. 2013. PMID: 24161933
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