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Editorial
. 2013 Dec 15;12(24):3713-4.
doi: 10.4161/cc.26976. Epub 2013 Oct 28.

Pol κ in replication checkpoint

Domenico Maiorano  1 , Jean-Sébastien Hoffmann  2
Affiliations
Editorial

Pol κ in replication checkpoint

Domenico Maiorano et al. Cell Cycle. .
No abstract available

Keywords: 9-1-1; ATR; Chk1; DNA damage; TLS DNA polymerase; cell cycle; chromatin; replication stress; ssDNA.

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Figures

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Figure 1. Speculative model of Pol κ function in replication checkpoint. Upon replication fork stalling with replicative DNA polymerases inhibitors (hydroxyurea, aphidicolin) or UV-blocking lesions, ssDNA is generated by the action of the helicase (CMG complex). Replicative DNA polymerases α and δ as well as TLS polymerase Pol κ contribute to synthesis and/or stabilization of small replication intermediates. These structures are bound by the checkpoint clamp 9-1-1 complex. DNA Pol κ may interact with the 9-1-1 complex on chromatin, thus facilitating local formation of the active ATR complex that include ATRIP and ToPBP1. Pol κ may also be implicated in replication fork restart by repriming (question mark).
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References

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