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Comment
. 2013 Dec 15;12(24):3718-9.
doi: 10.4161/cc.26975. Epub 2013 Oct 28.

miR-29b: a new demethylator in multiple myeloma

Leonidas Benetatos  1
Affiliations
Comment

miR-29b: a new demethylator in multiple myeloma

Leonidas Benetatos. Cell Cycle. .
No abstract available

Keywords: SOCS-1; STAT3; demethylation; miR-29b; microRNAs; multiple myeloma.

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Figures

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Figure 1. In malignant plasma cells, the initial downregution of miR-29b results in increased levels of DNMT3a/b which in turn causes epigenetic silencing of SOCS-1, increases STAT3 phosphorylation, and upregulation of downstream factors promoting angiogenesis, proliferation, and migration of plasma cells. miR-29b mimics transfection downregulates DNMT3a/b, leading to enhanced SOCS-1 expression which subsequently inhibits STAT3 phosphorylation and indirectly blocks downstream effectors.
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