Infectious disease: hushing mTOR boosts immunity to pathogens

Comment

Yvonne Bordon. Nat Rev Immunol. 2013 Dec.

. 2013 Dec;13(12):847.

doi: 10.1038/nri3562. Epub 2013 Nov 5.

No abstract available

Comment on

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR.
Ivanov SS, Roy CR. Ivanov SS, et al. Nat Immunol. 2013 Dec;14(12):1219-28. doi: 10.1038/ni.2740. Epub 2013 Oct 13. Nat Immunol. 2013. PMID: 24121838 Free PMC article.
The kinase mTOR modulates the antibody response to provide cross-protective immunity to lethal infection with influenza virus.
Keating R, Hertz T, Wehenkel M, Harris TL, Edwards BA, McClaren JL, Brown SA, Surman S, Wilson ZS, Bradley P, Hurwitz J, Chi H, Doherty PC, Thomas PG, McGargill MA. Keating R, et al. Nat Immunol. 2013 Dec;14(12):1266-76. doi: 10.1038/ni.2741. Epub 2013 Oct 20. Nat Immunol. 2013. PMID: 24141387 Free PMC article.