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Review
. 2013 Dec;8(4):299-306.
doi: 10.1007/s11899-013-0184-z.

Genetic basis of MPN: Beyond JAK2-V617F

Nicole C C Them  1 , Robert Kralovics
Affiliations
Review

Genetic basis of MPN: Beyond JAK2-V617F

Nicole C C Them et al. Curr Hematol Malig Rep. 2013 Dec.

Abstract

The clonal blood disorders polycythemia vera, essential thrombocythemia and primary myelofibrosis belong to the BCR-ABL1-negative myeloproliferative neoplasms and are specified by increased production of terminally differentiated myeloid cells. Clonal evolution, disease initiation and progression are influenced by genetic alterations, often affecting cytokine signaling and gene expression. This review outlines somatic changes discovered in myeloproliferative neoplasms and how these genetic aberrations influence the pathogenesis of myeloproliferative neoplasms. Furthermore, genetic responses to drug treatments in myeloproliferative neoplasms are discussed.

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