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Review
. 2013 Dec;13(12):409.
doi: 10.1007/s11910-013-0409-5.

Depression and Parkinson's disease: current knowledge

Laura Marsh  1
Affiliations
Review

Depression and Parkinson's disease: current knowledge

Laura Marsh. Curr Neurol Neurosci Rep. 2013 Dec.

Abstract

Depressive disturbances are common in patients with Parkinson's disease (PD) and influence many other clinical aspects of the disease. In addition to causing inherent emotional distress, depressive disorders negatively impact quality of life, motor and cognitive deficits, functional disability, and other psychiatric comorbidities in patients with PD. Knowledge of the pathophysiology of PD depression remains limited. However, clinical studies demonstrate the efficacy of medications and psychotherapies for PD depression, underscoring the importance of their timely detection and concerted management.

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Conflict of interest statement

Compliance with Ethics Guidelines

Conflict of Interest Laura Marsh has been a consultant for Roche Pharmaceuticals for the development of clinical trial designs to test interventions for apathy in Parkinson's disease. She is employed by the Michael E. DeBakey Veterans Affairs Medical Center. She is a site investigator for the Dystonia Coalition U54 NS065701.

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