doi: 10.1016/0014-2999(86)90547-9.
Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide
- PMID: 2419150
- DOI: 10.1016/0014-2999(86)90547-9
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Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide
Eur J Pharmacol.
.
Abstract
In the guinea-pig myenteric plexus-longitudinal muscle preparation from the small intestine, the release of acetylcholine evoked by substance P and vasoactive intestinal polypeptide was examined in vitro. Both neuropeptides stimulated efflux of [3H]acetylcholine from myenteric neurons in a calcium-dependent manner. This observation is consistent with the view that neurotransmitter release elicited by neuropeptides requires the presence of extracellular calcium ions.
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