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. 1986 Jan 21;120(2):241-3.
doi: 10.1016/0014-2999(86)90547-9.

Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide

W M Yau, J A Dorsett, M L Youther

Calcium-dependent stimulation of acetylcholine release by substance P and vasoactive intestinal polypeptide

W M Yau et al. Eur J Pharmacol. .

Abstract

In the guinea-pig myenteric plexus-longitudinal muscle preparation from the small intestine, the release of acetylcholine evoked by substance P and vasoactive intestinal polypeptide was examined in vitro. Both neuropeptides stimulated efflux of [3H]acetylcholine from myenteric neurons in a calcium-dependent manner. This observation is consistent with the view that neurotransmitter release elicited by neuropeptides requires the presence of extracellular calcium ions.

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