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. 2013 Dec;11(12):1303-32.
doi: 10.1586/14787210.2013.851601. Epub 2013 Nov 6.

On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections

R Matthew Chico  1 , Berkin B Hack, Melanie J Newport, Enesia Ngulube, Daniel Chandramohan
Affiliations
Free PMC article

On the pathway to better birth outcomes? A systematic review of azithromycin and curable sexually transmitted infections

R Matthew Chico et al. Expert Rev Anti Infect Ther. 2013 Dec.
Free PMC article

Abstract

The WHO recommends the administration of sulfadoxine-pyrimethamine (SP) to all pregnant women living in areas of moderate (stable) to high malaria transmission during scheduled antenatal visits, beginning in the second trimester and continuing to delivery. Malaria parasites have lost sensitivity to SP in many endemic areas, prompting the investigation of alternatives that include azithromycin-based combination (ABC) therapies. Use of ABC therapies may also confer protection against curable sexually transmitted infections and reproductive tract infections (STIs/RTIs). The magnitude of protection at the population level would depend on the efficacy of the azithromycin-based regimen used and the underlying prevalence of curable STIs/RTIs among pregnant women who receive preventive treatment. This systematic review summarizes the efficacy data of azithromycin against curable STIs/RTIs.

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Figures

Figure 1.
Figure 1.
Identification, screening and eligibility of studies included in systematic review.
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References

    1. WHO WHO Policy Recommendation: Intermittent Preventive Treatment of Malaria in Pregnancy using Sulfadoxine-Pyrimethamine (IPTp-SP) Apr 11, 2013. 2013.
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Website

    1. ReMeD (Network for Medicine and Development) Essential Medicines: Madagascar. www.who.int/selection_medicines/country_lists/mdg/en/ World Health Organization.

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