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Comparative Study
. 2014 Feb 4;129(5):570-9.
doi: 10.1161/CIRCULATIONAHA.113.005757. Epub 2013 Nov 5.

Racial/ethnic differences in dyslipidemia patterns

Ariel T H Frank  1 , Beinan Zhao, Powell O Jose, Kristen M J Azar, Stephen P Fortmann, Latha P Palaniappan
Affiliations
Comparative Study

Racial/ethnic differences in dyslipidemia patterns

Ariel T H Frank et al. Circulation. .

Abstract

Background: No studies have comprehensively examined the prevalence of dyslipidemia, a major risk factor for cardiovascular disease, among diverse racial/ethnic minority groups. The primary aim of this study was to identify racial/ethnic differences in dyslipidemia among minorities including Asian Americans (Asian Indian, Chinese, Filipino, Japanese, Korean, or Vietnamese), Mexican Americans, and blacks compared with non-Hispanic whites.

Methods and results: Using a 3-year cross section (2008-2011), we identified 169 430 active primary care patients (35 years or older) from an outpatient healthcare organization in northern California. Age-standardized prevalence rates were calculated for 3 dyslipidemia subtypes: high triglycerides (fasting laboratory value ≥150 mg/dL), low levels of high-density lipoprotein cholesterol (fasting laboratory value <40 mg/dL [men] and <50 mg/dL [women]), and high levels of low-density lipoprotein cholesterol (fasting laboratory value ≥130 mg/dL or taking low-density lipoprotein-lowering agents). Odds ratios were calculated by multivariable logistic regression, with adjustment for patient characteristics (age, measured body mass index, smoking). Compared with non-Hispanic whites, every minority subgroup had an increased prevalence of high triglycerides except blacks. Most minority groups had an increased prevalence of low high-density lipoprotein cholesterol, except for Japanese and blacks. The prevalence of high low-density lipoprotein cholesterol was increased among Asian Indians, Filipinos, Japanese, and Vietnamese compared with non-Hispanic whites.

Conclusions: Minority groups, except for blacks, were more likely to have high triglyceride/low high-density lipoprotein cholesterol dyslipidemia. Further research is needed to determine how racial/ethnic differences in dyslipidemia affect racial/ethnic differences in cardiovascular disease rates.

Keywords: epidemiology; hyperlipoproteinemias; lipids; lipoproteins; pharmaceutical preparations; risk factors.

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Conflict of interest statement

CONFLICTS OF INTEREST

All authors declare they have no conflicts of interest.

Figures

Figure 1
Figure 1
Prevalence Odds Ratios for Racial/Ethnic Differences in Dyslipidemia Subtypes (N=169,430) LDL-C=low-density lipoprotein cholesterol; HDL-C=high-density lipoprotein cholesterol; TG=triglycerides; Multivariable-adjusted model included age, body-mass index (BMI), primary insurance, and smoking status. The square indicates the point estimate and the bar represents the 99.9% CI. Filled squares indicate statistical significance compared with Non-Hispanic Whites at p<0.001.
Figure 2
Figure 2
Prevalence Odds Ratios for Racial/Ethnic Differences in Dyslipidemia Subtypes Stratified by Cardiovascular Disease
See this image and copyright information in PMC

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