doi: 10.1128/jb.165.3.1046-1048.1986.
Escherichia coli tryptophan operon directs the in vivo synthesis of a leader peptide
- PMID: 2419306
- PMCID: PMC214539
- DOI: 10.1128/jb.165.3.1046-1048.1986
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Escherichia coli tryptophan operon directs the in vivo synthesis of a leader peptide
J Bacteriol.
1986 Mar.
Abstract
Here we report the identification of the Escherichia coli trp leader peptide synthesized in vivo. We identified the peptide in UV-irradiated maxicells by selective labeling with radioactive amino acids which are included in the predicted sequence of this peptide. Our results support the hypothesis that translation of the peptide-coding region of the leader RNA has a role in the mechanism of attenuation of biosynthetic operons in general and in the E. coli trp operon in particular.
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