Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2010 Aug 26:3:105-17.
doi: 10.2147/SCCAA.S6815.

Hematopoietic stem cell transplantation

Eleftheria Hatzimichael  1 , Mark Tuthill
Affiliations
Review

Hematopoietic stem cell transplantation

Eleftheria Hatzimichael et al. Stem Cells Cloning. .

Abstract

More than 25,000 hematopoietic stem cell transplantations (HSCTs) are performed each year for the treatment of lymphoma, leukemia, immune-deficiency illnesses, congenital metabolic defects, hemoglobinopathies, and myelodysplastic and myeloproliferative syndromes. Before transplantation, patients receive intensive myeloablative chemoradiotherapy followed by stem cell "rescue." Autologous HSCT is performed using the patient's own hematopoietic stem cells, which are harvested before transplantation and reinfused after myeloablation. Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response, and the development of a graft versus leukemia effect. This article reviews the biology of stem cells, clinical efficacy of HSCT, transplantation procedures, and potential complications.

Keywords: complications; hematopoietic stem cell transplantation.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The mobilization and homing of hematopoietic stem cells (HSCs) to the bone marrow niches of the transplant recipient. Abbreviations: vLA-4/5, very late activation antigen; SDF-1, stromal cell-derived factor-1; G-CSF, granulocyte colony-stimulating factor.
See this image and copyright information in PMC

References

    1. Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol. 2006;169:338–346. - PMC - PubMed
    1. Shizuru JA, Negrin RS, Weissman IL. Hematopoietic stem and progenitor cells: clinical and preclinical regeneration of the hematolymphoid system. Annu Rev Med. 2005;56:509–538. - PubMed
    1. Ogawa M. Differentiation and proliferation of hematopoietic stem cells. Blood. 1993;81:2844–2853. - PubMed
    1. Alcorn MJ, Holyoake TL, Richmond L, et al. CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity. J Clin Oncol. 1996;14:1839–1847. - PubMed
    1. Zandstra PW, Lauffenburger DA, Eaves CJ. A ligand-receptor signaling threshold model of stem cell differentiation control: a biologically conserved mechanism applicable to hematopoiesis. Blood. 2000;96:1215–1222. - PubMed