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Review
. 2010 Mar 12:2:35-40.

Pazopanib and anti-VEGF therapy

Harry A Drabkin  1
Affiliations
Review

Pazopanib and anti-VEGF therapy

Harry A Drabkin. Open Access J Urol. .

Abstract

Pazopanib (Votrient™, GlaxoSmithKline), a multi-kinase inhibitor with activity against VEGFR and other receptors, was recently approved by the FDA for the treatment of advanced renal cell carcinoma (RCC). Here, we review the history of its development, together with an overview of VEGF and its receptors and co-receptors. Results from selected clinical trial data in RCC and other malignant diseases are presented. Based on available evidence, pazopanib is an effective VEGFR inhibitor with demonstrable clinical activity in metastatic RCC and promising activity in other diseases. Like most kinase inhibitors, its activity is not restricted to VEGF receptors, which is reflected in its side-effect profile.

Keywords: VEGFR; pazopanib; renal cell carcinoma.

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Figures

Figure 1
Figure 1
Schematic showing neuropilin1/2, VEGFR1/2 and plexin A receptors/co-receptors and their various ligands. The neuropilins function as co-receptors for various VEGF ligands, whereas the plexins are co-receptors for Sema3s. Abbreviations: FGR, fibroblast growth factor; HGF, hepatocyte growth factor.
Figure 2
Figure 2
The structure of pazopanib (cmpd 13).
See this image and copyright information in PMC

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