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Comparative Study
. 2013 Oct;26(5):531-41.
doi: 10.1177/197140091302600506. Epub 2013 Nov 7.

Advanced MR imaging techniques in the evaluation of nonenhancing gliomas: perfusion-weighted imaging compared with proton magnetic resonance spectroscopy and tumor grade

Neslin Sahin  1 , Elias R Melhem, Sumei Wang, Jaroslaw Krejza, Harish Poptani, Sanjeev Chawla, Gaurav Verma
Affiliations
Comparative Study

Advanced MR imaging techniques in the evaluation of nonenhancing gliomas: perfusion-weighted imaging compared with proton magnetic resonance spectroscopy and tumor grade

Neslin Sahin et al. Neuroradiol J. 2013 Oct.

Abstract

A significant number of nonenhancing (NE) gliomas are reported to be malignant. The purpose of this study was to compare the value of advanced MR imaging techniques, including T2*-dynamic susceptibility contrast PWI (DSC-PWI) and proton magnetic resonance spectroscopy ((1)HMRS) in the evaluation of NE gliomas. Twenty patients with NE gliomas underwent MRI including DSC-PWI and (1)HMRS. The relative CBV (rCBV) measurements were obtained from regions of maximum perfusion. The peak ratios of choline/creatine (Cho/Cr) and myo-inositol/creatine (mIns/Cr) were measured at a TE of 30 ms. Demographic features, tumor volumes, and PWI- and (1)HMRS-derived measures were compared between low-grade gliomas (LGGs) and high-grade gliomas (HGGs). In addition, the association of initial rCBV ratio with tumor progression was evaluated in LGGs. No significant difference was noted in age, sex or tumor size between LGGs and HGGs. Cho/Cr ratios were significantly higher in HGGs (1.7±0.63) than in LGGs (1.2±0.38). The receiver operating characteristic analysis demonstrated that a Cho/Cr ratio with a cutoff value of 1.3 could differentiate between LGG and HGG with a specificity of 100% and a sensitivity of 71.4%. There was no significant difference in the rCBV ratio and the mIns/Cr ratio between LGG and HGG. However, higher rCBV ratios were observed with more rapid progressions in LGGs. The results imply that Cho/Cr ratios are useful in distinguishing NE LGG from HGG and can be helpful in preoperative grading and biopsy guidance. On the other hand, rCBV ratios do not help in the distinction.

Keywords: MR spectroscopy; nonenhancing glioma; perfusion MRI.

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Figures

Figure 1
Figure 1
A 53-year-old man with grade II oligodendroglioma. A) There is no contrast enhancement on the contrast-enhanced axial T1-weighted image. B) DSC-PWI with rCBV color overlay map shows increased perfusion with a high rCBV of 3.34, in keeping with a high-grade glioma. C) 1HMRS demonstrates a Cho/Cr ratio of 1.3, in keeping with a low-grade glioma.
Figure 2
Figure 2
A 35-year-old man with grade III anaplastic oligodendroglioma. A) There is no contrast enhancement on the contrast-enhanced axial T1-weighted image. B) DSC-PWI with rCBV color overlay map shows high perfusion with a rCBV of 3.8, in keeping with a high-grade glioma. C) 1HMRS demonstrates a Cho/Cr ratio of 2.7, in keeping with a high-grade glioma.
Figure 3
Figure 3
A 37-year-old man with grade III anaplastic oligodendroglioma. A) There is no contrast enhancement on the contrast-enhanced axial T1-weighted image. B) DSC-PWI with rCBV color overlay map shows low perfusion with a rCBV of 0.73, in keeping with a low-grade glioma. C) 1HMRS demonstrates a Cho/Cr ratio of 1.55, in keeping with a high-grade glioma.
Figure 4
Figure 4
Cho/Cr ratio for low-grade (LGG) and high-grade (HGG) gliomas. The Cho/Crmax ratio of HGGs was significantly higher than that of LGGs (P > 0.003).
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