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. 2013 Nov 22;76(11):2158-61.
doi: 10.1021/np4007074. Epub 2013 Nov 7.

Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

Sunan Jaisamut  1 , Samran Prabpai, Chompoonuch Tancharoen, Supreeya Yuenyongsawad, Supa Hannongbua, Palangpon Kongsaeree, Anuchit Plubrukarn
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Bridged tricyclic sesquiterpenes from the tubercle nudibranch Phyllidia coelestis Bergh

Sunan Jaisamut et al. J Nat Prod. .

Abstract

A new sesquiterpene, 1-formamido-10(1→2)-abeopupukeanane (1), was isolated from the tubercle nudibranch Phyllidia coelestis Bergh, along with 2-formamidopupukeanane (2), which is reported here as a natural product for the first time. A rearrangement pathway toward the unprecedented tricyclo[4.4.0.0(2,8)]decane skeleton is proposed. Both compounds showed antiproliferative activity when targeting HeLa, MCF-7, KB, and HT-29 cancer cell lines in the range 0.05-10 μM.

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