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. 2014 Jan:21:54-7.
doi: 10.1016/j.meegid.2013.10.019. Epub 2013 Nov 5.

A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing

Vartul Sangal  1 , Andreas Burkovski  2 , Alison C Hunt  3 , Becky Edwards  4 , Jochen Blom  5 , Paul A Hoskisson  6
Affiliations

A lack of genetic basis for biovar differentiation in clinically important Corynebacterium diphtheriae from whole genome sequencing

Vartul Sangal et al. Infect Genet Evol. 2014 Jan.

Abstract

The differentiation of clinically important Corynebacterium diphtheriae into specific biovars is complex and phylogenetically unclear. Comparative genomic analyses of 17 strains indicate that the division of C. diphtheriae into different biovars does not correlate with the variation in the gene content in the relevant metabolic categories that are potentially involved in the biovar discrimination. The biochemical separation is also not supported by phylogenetic analyses, suggesting molecular methods of typing C. diphtheriae strains should be adopted much more widely.

Keywords: Biovar; Corynebacterium diphtheriae; Gene contents; Genomic comparison; Pseudogenes; SNPs.

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