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. 2014 May-Jun;12(3):268-73.
doi: 10.1016/j.tmaid.2013.10.010. Epub 2013 Oct 30.

False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: a case control study

Ryan C Maves  1 , Katherine Dean  2 , Nilda Gadea  3 , Eric S Halsey  3 , Paul C F Graf  4 , Andres G Lescano  3
Affiliations

False-positive rapid plasma reagin testing in patients with acute Plasmodium vivax malaria: a case control study

Ryan C Maves et al. Travel Med Infect Dis. 2014 May-Jun.

Abstract

Non-treponemal tests such as the rapid plasma reagin (RPR) assay are mainstays of syphilis diagnosis, but false-positive tests are common. We identified false-positive RPR titers in 8.2% of patients with malaria due to Plasmodium vivax in northern Peru. Similar rates were not detected in patients with other acute febrile illnesses.

Keywords: Diagnostic test; Syphilis; Vivax malaria.

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Conflict of interest statement

Conflict of interest

None.

Figures

Figure 1
Figure 1
Centers for Disease Control and Prevention diagnostic algorithms for syphilis. In the traditional algorithm, a screening quantitative RPR is followed by a confirmatory treponemal assay. In the reverse algorithm, an EIA or CIA specific for Treponema pallidum replaces the RPR as the screening test; a positive EIA or CIA is followed by a confirmatory RPR. If that RPR is negative, a second treponemal test is performed to verify the results. RPR = rapid plasma reagin; TP-HA = T. pallidum hemoagglutination test; TP-PA = T. pallidum particle agglutination test; EIA = enzyme immunoassay; CIA = chemiluminescence immunoassay.
See this image and copyright information in PMC

References

    1. Tucker JD, Bu J, Brown LB, Yin YP, Chen XS, Cohen MS. Accelerating worldwide syphilis screening through rapid testing: a systematic review. Lancet Infect Dis. 2010;10:381–386. - PubMed
    1. Carcamo CP, Campos PE, Garcia PJ, Hughes JP, Garnett GP, Holmes KK, et al. Prevalences of sexually transmitted infections in young adults and female sex workers in Peru: a national population-based survey. Lancet Infect Dis. 2012;12:765–773. - PMC - PubMed
    1. Zetola NM, Klausner JD. Syphilis and HIV infection: an update. Clin Infect Dis. 2007;44:1222–1228. - PubMed
    1. Owusu-Edusei K, Jr, Peterman TA, Ballard RC. Serologic testing for syphilis in the United States: a cost-effectiveness analysis of two screening algorithms. Sex Transm Dis. 2011;38:1–7. - PubMed
    1. Snounou G, Viriyakosol S, Jarra W, Thaithong S, Brown KN. Identification of the four human malaria parasite species in field samples by the polymerase chain reaction and detection of a high prevalence of mixed infections. Mol Biochem Parasitol. 1993;58:283–292. - PubMed

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