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Review
. 2013 Dec;14(12):839-50.
doi: 10.1038/nrn3642. Epub 2013 Nov 8.

AMPA-silent synapses in brain development and pathology

Eric Hanse  1 , Henrik Seth, Ilse Riebe
Affiliations
Review

AMPA-silent synapses in brain development and pathology

Eric Hanse et al. Nat Rev Neurosci. 2013 Dec.

Abstract

Synapses are constantly generated at a high rate in the developing, prepubescent brain. Newly generated glutamatergic synapses lack functional AMPA receptor-mediated transmission. Most of these 'AMPA-silent' synapses are eliminated during the developmental period, but some are specifically selected for AMPA unsilencing by correlated pre-and postsynaptic activity as the first step in a process that leads to stabilization of the synapse. Premature, or delayed, unsilencing of AMPA-silent synapses has been implicated in neurodevelopmental disorders, and abnormal generation of AMPA-silent synapses is associated with brain trauma, addiction and neurodegenerative disorders, further highlighting the importance of AMPA-silent synapses in brain pathology.

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References

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